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After 4 years on the market, Apple has discontinued its original HomePod. It says that it will continue to produce and focus on the HomePod mini, introduced last year. The larger HomePod offered a beefier sound space but the mini has been very well received and clearly accomplishes many of the duties that the larger version was tasked with. The sound is super solid (especially for the size) and it offers access to Siri, Apple’s assistant feature.

The original HomePod was a feat of audio engineering that Apple spent over 5 years developing. In order to accomplish its development, the team at Apple built out a full development center near its headquarters in Cupertino, with a world-class development environment with a dozen anechoic chambers, including one of the bigger anechoic chambers outside of academic use in the US. I visited the center before its release, noting that Apple took it the extra mile to get the incredibly complex series of tweeters and woofer that built its soundspace:

But slathered on top of that is a bunch of typically Apple extra-mile jelly. Apple says that its largest test chamber is one of the biggest in the US, on a pad, suspended from the outside world with nothing to pollute its tests of audio purity. Beyond testing for the acoustic qualities of the speaker, these chambers allowed Apple to burrow down to account for and mitigate the issues that typically arise from having a high excursion subwoofer in such a small cabinet. Going even further, there are smaller chambers that allow them to isolate the hum from electronic components (there is a computer on board after all) and make attempts to insulate and control that noise so it doesn’t show up in the final output.

I found it to be one of the best speakers ever made for the home when I reviewed it in 2018. From the booming base and well-shaped nature of the tweeter assembly inside; the cloth cover that was specially shaped to avoid interfering with sound quality in any way; the way that it sensed the way that audio was being shaped by walls and other obstructions and adjusted its output to compensate. It was the definition of ‘no effort spared’ in the speaker department.

The major gripe for the speaker at the time was the $349 price, which was at the top end of the home speaker market, especially those with embedded home assistants. A price drop to $299 mitigated that somewhat, but still put it at the top of the pricing umbrella for the class. Apple’s HomePod mini, launched last year, has been well received. Our Brian Heater said that it had ‘remarkably big sound’ for the $99 price.

Apple gave TechCrunch a statement about the discontinuation:

HomePod mini has been a hit since its debut last fall, offering customers amazing sound, an intelligent assistant, and smart home control all for just $99. We are focusing our efforts on HomePod mini. We are discontinuing the original HomePod, it will continue to be available while supplies last through the Apple Online Store, Apple Retail Stores, and Apple Authorized Resellers. Apple will provide HomePod customers with software updates and service and support through Apple Care.

Existing HomePods will continue to be sold but Apple’s website is already out of Space Gray. It will continue to provide support for existing HomePods. Apple seems to be betting on the mini going forward, which could point to their desire to fill every room with ‘good enough’ sound rather than to focus on the living room with ‘truly unbelievable’ sound. The HomePod itself never quite got to the level where it could act as a full home theater replacement, though paired in their multi-speaker configurations.

The HomePod research and production efforts will live on in some ways through Apple’s advanced audio rendering systems that led to things like Spatial Audio in AirPods. I quite enjoy the ones in my home and have yet to add any minis to the mix. Maybe a last minute hunt is in order.

A prominent Republican senator weighs in on Amazon’s labor disputes, Microsoft reports a security vulnerability in Exchange and we examine ByteDance’s gaming strategy. This is your Daily Crunch for March 12, 2021.

The big story: Marco Rubio sides with Amazon workers

Senator Marco Rubio published an op-ed in USA Today declaring his support for workers in Amazon’s warehouse in Bessemer, Alabama, as they seek to unionize.

It’s surprising for a Republican senator to throw his weight behind a nascent labor union, but it seems that Rubio’s position has as much to do with his feelings about Amazon as his labor politics. In fact, his op-ed warned of the “dangers posed by the unchecked influence of labor unions,” while also arguing that Amazon is guilty of “uniquely malicious corporate behavior.”

The tech giants

Hackers are exploiting vulnerable Exchange servers to drop ransomware, Microsoft says — This puts tens of thousands of email servers at risk of destructive attacks.

How ByteDance plans to crack the gaming industry — The company’s strategy consists of a genre-spanning portfolio, a hiring spree, a proven monetization scheme, and a focus on both the domestic and overseas markets.

Elon Musk, Tesla board sued in lawsuit alleging ‘erratic’ tweets violate fiduciary duty — A Tesla investor is suing the company board and Musk for continuing to send “erratic tweets” that violate a settlement with the U.S. Securities and Exchange Commission that requires oversight of his social media activities.

Startups, funding and venture capital

Assembled, an operating system for support teams, raises $16.6M — The round was led by Emergence Capital, a VC that specializes in enterprise startups.

Eying sustainability gains for its supply chain, BMW backs Boston Metal’s CO2-free iron production tech — The Boston startup had targeted a $50 million raise earlier in the year, and BMW’s addition closes out that round.

Legl gets $7M to help law firms upgrade to digital workflows — The Legl platform offers tools to streamline core business processes such as customer onboarding, due diligence and payments.

Advice and analysis from Extra Crunch

How nontechnical talent can break into deep tech — Tactical advice for finding, reaching out to, cultivating relationships with, and working at deep tech companies.

US-listed SPACs have a new target: Latin American tech companies — There has been an unprecedented IPO boom of tech companies in the Brazilian stock exchange.

Why I’m hitting pause on ARR-focused coverage — Alex Wilhelm says that ultimately, he was getting similar notes from each company.

Everything else

Big Tech companies cannot be trusted to self-regulate: We need Congress to act — Thoughts from Color of Change’s Arisha Hatch.

Here are the new features and upgraded virtual Startup Alley experience at TC Disrupt 2021 — This year, we’re shaking things up a bit to help exhibiting founders make the most of a virtual environment.

The Daily Crunch is TechCrunch’s roundup of our biggest and most important stories. If you’d like to get this delivered to your inbox every day at around 3pm Pacific, you can subscribe here.

Immune intelligence startup Serimmune hopes to better understand the relationship between antibody epitopes (the parts of antigen molecules that bind to antibodies) and the SARS-CoV-2 virus.

The company’s proprietary technology, originally developed at UC Santa Barbara, provides a new and specific way of mapping the entire array of an individual’s antibodies through a small blood sample. They do this through the use of a bacterial peptide display—a sort of screening mechanism that can isolate plasmid DNA from antibody-bound bacteria in the sample. This DNA can then be sequenced to identify epitopes, which provide information about both which antigens someone may have been exposed to, as well as how his or her immune system responded to them.

“It’s a very highly multiplexed and exquisitely specific way of looking at the epitopes found by antibodies in a specimen,” said Serimmune CEO Noah Nasser, who has a degree in molecular biology from UC San Diego and has previously worked for several diagnostics companies.

This week, Serimmune announced the launch of a new application of their core technology to help understand the disease states of and immune responses to SARS-CoV-2, or the virus that causes COVID-19.

“So what we do is we take these antibody profiles we build, and we’re able to then map those back with about a 12 amino acid specificity to the SARS-CoV-2 proteome,” said Nasser. “And what we find is that antibody expression is highly correlated to disease state, so we can distinguish mild, moderate, severe and asymptomatic disease on the basis of antibodies that are present in the specimen.”

The more patient data Serimmune can collect, the better its core technology becomes at finding patterns across different antigen exposure and disease severity. Noticing those patterns sooner won’t only help physicians and researchers to better understand how the SARS-CoV-2 virus operates, but can also inform new approaches to diagnostics, treatments, and vaccines for any antigen.

Serimmune’s launch of its new COVID antibody epitope mapping service is a way of making this data more accessible to customers like vaccine companies, government agencies, and academic labs that have shown interest in better understanding the immune response to SARS-CoV-2.

“The key was to zero in on the information that researchers wanted to know and standardize that,” said Nasser. “We can actually now provide these results back in as few as two days from sample receipt.”

Beyond this new service, Serimmune also has plans to launch a longitudinal clinical study on immunity to SARS-CoV-2. Using a painless at-home collection kit, study participants send in small blood samples to Serimmune, which then uses its core technology to outline an individual immunity map.

“We provide their results back to them in the form of a personal immune landscape to COVID,” said Nasser. “And what we’re trying to do is to understand over time how that immune response changes, and what happens to that immune response on repeated exposure to COVID.”

The mapping technology is now so specific that it can tell whether or not a patient has antibodies from natural exposure to the SARS-CoV-2 virus or from a vaccine, he added.

While the primary focus for Serimmune remains these applications to the COVID-19 pandemic for now, Nasser also mentioned that the company has plans to move into personalized medicine, potentially offering their mapping service directly to interested patients.

“We believe that this has value to individual patients in understanding their immune status and what antigens they’ve been exposed to,” he said. Until then, Serimmune plans to continue growing its database with more patient samples.

Hackers are exploiting recently discovered vulnerabilities in Exchange email servers to drop ransomware, Microsoft has warned, a move that puts tens of thousands of email servers at risk of destructive attacks.

In a tweet late Thursday, the tech giant said it had detected the new kind of file-encrypting malware called DoejoCrypt — or DearCry — which uses the same four vulnerabilities that Microsoft linked to a new China-backed hacking group called Hafnium.

When chained together, the vulnerabilities allow a hacker to take full control of a vulnerable system.

Microsoft said Hafnium was the “primary” group exploiting these flaws, likely for espionage and intelligence gathering. But other security firms say they’ve seen other hacking groups exploit the same flaws. ESET said at least 10 groups are actively compromising Exchange servers.

Michael Gillespie, a ransomware expert who develops ransomware decryption tools, said many vulnerable Exchange servers in the U.S., Canada, and Australia had been infected with DearCry.

The new ransomware comes less than a day after a security researcher published proof-of-concept exploit code for the vulnerabilities to Microsoft-owned GitHub. The code was swiftly removed a short time later for violating the company’s policies.

Marcus Hutchins, a security researcher at Kryptos Logic, said in a tweet that the code worked, albeit with some fixes.

Threat intelligence company RiskIQ says it has detected over 82,000 vulnerable servers as of Thursday, but that the number is declining. The company said hundreds of servers belonging to banks and healthcare companies are still affected, as well as more than 150 servers in the U.S. federal government.

That’s a rapid drop compared to close to 400,000 vulnerable servers when Microsoft first disclosed the vulnerabilities on March 2, the company said.

Microsoft published security fixes last week, but the patches do not expel the hackers from already-breached servers. Both the FBI and CISA, the federal government’s cybersecurity advisory unit, have warned that the vulnerabilities present a major risk to businesses across the United States.

John Hultquist, vice president of analysis at FireEye’s Mandiant threat intelligence unit, said he anticipates more ransomware groups trying to cash in.

“Though many of the still unpatched organizations may have been exploited by cyber espionage actors, criminal ransomware operations may pose a greater risk as they disrupt organizations and even extort victims by releasing stolen emails,” said Hultquist.

There has been an unprecedented IPO boom of tech companies in the Brazilian stock exchange, which is transformative for a market that was traditionally dominated by utilities, mining, oil and financial companies.

The trend continues to be strong; in February alone, growth companies like Bemobi, Westwing, Mobly and Mosaico went public. Mosaico, for example, was 20x oversubscribed and went up 70% on its first trading day. The same is true for other companies like Meliuz, Enjoei and Neogrid, up 173%, 53% and 74%, respectively, since their listing just a few months ago.

But what is even more surprising is that now, new special-purpose acquisition companies (SPACs) are raising money in Nasdaq with a mandate to buy Latin American private growth companies, which would be completely unthinkable just a year ago.

The opportunity for SPAC mergers in the U.S. has become quite competitive, as almost 300 SPACs, which raised over $90 billion, are now competing to find deals before the deadline. As a result, it has become more common to see SPACs with global mandates seeking to acquire foreign growth companies and list them in the U.S. to benefit from better multiples.

Just in 2021, eight Asian-sponsored SPACs raised over $2.3 billion in the Nasdaq/New York Stock Exchange, already surpassing the entire volume of 2020. More recently, it looks like the activity level may pick up in Brazil, and, potentially, in other Latin American countries, with $1.1 billion of Brazil-focused SPACs coming into fruition.