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TechCrunch is hosting a small virtual meetup this Thursday centered around Miami. We hope you can attend. It’s free.
This is our first (virtual) field trip to Miami. Even though we can’t be there physically right now, it’ll sure feel like we are. All lights will be shining on the Magic City. The area is quickly transforming thanks to active investors, interesting companies, a Twitter-proficient mayor and beautifully scenic living.
If you’re interested in what’s happening in Miami in general, seeking out a new, up-and-coming city to live in, looking for cool companies and talented founders to invest in, then you’ll want to register and drop March 11 on your calendar. This is a virtual event, but space is still limited, so register early.
Here’s just some of what you can expect:
- Networking – It’s what you can always count on us for. Companies are started and deals get done at TechCrunch events (yes, even the virtual ones!).
- Pitch-off – We’re going to tap into the local tech scene in Miami and bring on some VCs to take a look at your pitches. They’ll give you feedback live from the stage. Sign up to pitch by filling out this form.
- Panels – Meet the movers and shakers up close and personal. Hear about their journey, ask them questions and find out what’s special to them about Miami.
All along the way we’ll be asking for your feedback by way of polls, Q&As and surveys. We want to hear from everyone who lives in the birthplace of sunscreen, and we’re looking to you for suggestions on folks who should be getting all of the attention we can throw at them on March 11. Drop suggestions in the comments below.
It’s going to be one to remember, and it’s the perfect setup for when we can safely crash the city in person again!
Ann Arbor-based Refraction AI announced today that it has raised a $4.2 million seed round. The startup, which debuted on the TechCrunch Sessions: Mobility stage back in 2019, was founded by a pair of University of Michigan professors (Matthew Johnson-Roberson — now CTO — and Ram Vasudevan) seeking to solve a number of issues posed by many delivery robots.
With an initial prototype built on a bicycle foundation, the company’s REV-1 robot is designed to operate in bike lanes and roads, rather than the standard sidewalk ‘bot. The different approach allows the robot to travel at higher speeds (topping out at 15 miles per hour) and removes some of the messy pedestrian-dodging issues that come with sidewalk use (while introducing some new ones on that narrow sliver of asphalt shared by cyclists).
Refraction is currently testing a small fleet in its native Ann Arbor. The seed round, led by Pillar VC, will be used for R&D, expanding the company’s reach and recruiting more customers, with a focus on grocery store and restaurant deliveries. Other investors include, eLab Ventures, Osage Venture Partners, Trucks Venture Capital, Alumni Ventures Group, Chad Laurans and Invest Michigan.
Another key differentiator is the use of cameras, versus LIDAR. The decision comes with some technological trade-offs, but benefits include a lower price point and the ability for the company to more quickly scale its fleet. The technology is also not easily districted by weather conditions encountered in the upper midwest, though it has limitations, too. As the company puts it, if you’re not comfortable walking out in it, the robot probably won’t be, either.
“Our platform uses technology that exists today in an innovative way, to get people the things they need, when they need them, where they live,” CEO Luke Schneider said in a release tied to the news. “And we’re doing so in a way that reduces business’ costs, makes roads less congested, and eliminates carbon emissions.”
With this new funding, the company plans to expand operations beyond its native Ann Arbor, though no additional test markets have been announced.
Antibiotic resistance is one of the biggest potential threats to global health today. But Locus Biosciences is hoping that their crPhage technology might provide a new solution.
Based in North Carolina’s Research Triangle, the startup recently announced promising phase 1b clinical trial results for their use of CRISPR-Cas3-enhanced bacteriophages as a treatment for urinary tract infections caused by escherichia coli. Led in part by former Patheon executive and current Locus CEO Paul Garofolo, the startup launched in 2015 with the goal of using a less popular application of CRISPR technology to address growing antimicrobial resistance.
CRISPR-Cas3 technology has notably different mechanisms from its more well-known CRISPR-Cas9 counterpart. Where the Cas9 enzyme has the ability to cleanly cut through a piece of DNA like a pair of scissors, Garofolo describes Cas3 more like a Pac-Man, shredding the DNA as it moves along a strand.
“You wouldn’t be able to use it for most of the editing platforms people were after,” he said, noting that meant there wouldn’t be as much competition around Cas3. “So I knew it would be protected for some time, and that we could keep it quiet.”
Garofolo and his team wanted to use CRISPR-Cas3 not to edit harmful bacteria found in the body, but to destroy it. To do this, they took the DNA-shredding mechanism of Cas3 and used it to enhance bacteriophages—viruses that can attack and kill different species of bacteria. Together, co-founder and Chief Scientific Officer Dave Ousterout—who has a Ph.D. in biomedical engineering from Duke—thinks this technology offers an extremely direct and targeted way of killing bacteria.
“We armed the phages with this Cas3 system that attacks E. coli, and that sort of dual mechanism of action is what comes together, essentially, as a really potent way to remove just E. coli,” he said in an interview.
That specificity is something that antibiotics lack. Rather than targeting only harmful bacteria in the body, antibiotics typically wipe out all bacteria they come across. “Every time we take antibiotics, we’re not thinking about all the other parts of us that are impacted by the bacteria that do good things,” said Garofolo. But the precision of Locus Biosciences’ crPhage technology means that only the targeted bacteria would be wiped out, leaving those necessary to the body’s normal function intact.
Beyond offering this more specific approach to treatment of pathogens, or any bacteria-based disease, Garofolo and his team also suspect that their approach will also be extremely safe. Though deadly to bacteria, bacteriophages are typically harmless to humans. The safety of CRISPR in humans is well-established, too.
“That’s our secret sauce,” said Garofolo. “We can build drugs that are more powerful than the antibiotics they’re trying to replace, and they use phage, which is probably one of the world’s safest ways to deliver something into the human body.”
While this new technology could certainly help treat pathogens and infectious diseases, Garofolo hopes that indications in immunology, oncology, and neurology might benefit from it too. “We’re starting to figure out that some bacteria might promote cancer, or inflammation in your gut,” he said. If researchers can identify the bacteria at the root cause of those conditions, Garofolo and Ousterout think the crPhage technology might prove to be an effective treatment.
“If we’re right about that, it’s not just about infections or antimicrobial resistance, but helping people overcome cancer or delay the onset of dementia,” Garofolo said. “It’s changing the way we think about how bacteria really help us live.”
Early Stage is the premier ‘how-to’ event for startup entrepreneurs and investors. You’ll hear first-hand how some of the most successful founders and VCs build their businesses, raise money and manage their portfolios. We’ll cover every aspect of company-building: Fundraising, recruiting, sales, product market fit, PR, marketing and brand building. Each session also has audience participation built-in – there’s ample time included for audience questions and discussion.
Planted, a startup pursuing a unique method of creating a vegetarian chicken alternative, has raised an $18M (CHF 17M) Series A to expand its product offerings and international footprint. With new kebabs and pulled-style faux meats available and steak-like cuts in the (literal) pipeline, Planted has begun to set its sights outside central Europe.
The company was a spinout from ETH Zurich and made its debut in 2019, but has not rested on the success of its plain chicken recipe. Its approach, which relied on using pea protein and pea fiber extruded to recreate the fibrous structure of chicken for nearly 1:1 replacement in recipes, has proven to be adaptable for different styles and ingredients as well.
“We aim to use different proteins, so that there is diversity, both in terms of agriculture and dietary aspects,” said co-founder Christoph Jenny.
Image Credits: Planted
“For example our newly launched planted.pulled consists of sunflower, oat and yellow pea proteins, changing both structure and taste to resemble pulled pork rather than chicken. The great thing about the sunflower proteins, they are upcycled from sunflower oil production. Hence, we are establishing a circular economy approach.”
When I first wrote about Planted, its products were only being distributed through a handful of restaurants and grocery stores. Now the company has a presence in more than 3,000 retail locations across Switzerland, Germany, and Austria, and works with restaurant and food service partners as well. No doubt this strong organic (so to speak) growth, and the growth of the meat alternative market in general, made raising money less of a chore.
The cash will be directed, as you might expect for a company at this stage, towards R&D and further expansion.
“The funding will be used to expand our tech stack, to commercialize our prime cuts that are currently produced at lab scale,” said Jenny. “On the manufacturing side we look to significantly increase our current capacity of half a ton per hour to serve the increasing demand coming from international markets, first in neighboring countries and then further into Europe and overseas.”
Image Credits: Planted
“We will further invest in our structuring and fermentation platforms. Combining structuring technologies with the biochemical toolboxes of natural microorganisms will allow us to create ultimately new products with transformative character – all clean, natural, healthy and tasty,” said co-founder Lukas Böni in a press release.
No doubt this all will also help lower the price, a goal from the beginning but only possible by scaling up.
As other companies in this space also raise money (incidentally, rather large amounts of it) and expand to other markets, competition will be fierce — but Planted seems to be specializing in a few food types that aren’t as commonly found, at least in the U.S., where sausages, ground “beef,” and “chicken” nuggets have been the leading forms of meat alternatives.
No word on when Planted products will make it to American tables, but Jenny’s “overseas” suggests it is at least a possibility fairly soon.
The funding round was co-led by Vorwerk Ventures and Blue Horizon Ventures, with participation from Swiss football (soccer) player Yann Sommer and several previous investors.
